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For a list of all publications on Pubmed, please click here.


Journal articles (selected)

Ripplinger CM, Glukhov AV, Kay MW, Boukens BJ, Chiamvimonvat N, Delisle BP, Fabritz L, Hund TJ, Knollmann BC, Li N, Murray KT, Poelzing S, Quinn TA, Remme CA, Rentschler SL, Rose RA, Posnack NG. Guildelines for assessment of cardiac electrophysiology and arrhythmias in small animals. Am J Physiol 2022;323:H1137-H1166. ABSTRACT | PDF

Jansen HJ, McRae MD, Mackasey M, Rose RA. Regional and temporal progression of atrial remodeling in angiotensin II mediated atrial fibrillation. Front Physiol 2022;13:1021807. ABSTRACT | PDF

Moghtadaei M, Dorey TW, Rose RA. Evaluation of nonlinear heart rate variability using multi-scale multi-fractal detrended fluctuation analysis in mice: roles of the autonomic nervous system and sinoatrial node. Front Physiol 2022;13:970393. ABSTRACT | PDF 

Dorey TW, Mackasey M, Jansen HJ, McRae MD, Bohne LJ, Liu Y, Belke DD, Atkinson L, Rose RA. Natriuretic peptide receptor B maintains heart rate and sinoatrial node function via cGMP-mediated signaling. Cardiovasc Res 2022;118:1917-1931 ABSTRACT | PDF

Jansen HJ, Moghtadaei M, Rafferty SA, Belke DD, Rose RA. Loss of natriuretic peptide receptor C enhances sinoatrial node dysfunction in aging and frail mice. J Gerontol A Biol Sci Med Sci 2022;77:902-908. ABSTRACT | PDF

Jamieson KL, Rose RA. New insights into ventricular arrhythmogenesis in a pure model of pulmonary arterial hypertension. Heart Rhythm 2022;19:125-126. ABSTRACT | PDF

Tuomi JM, Bohne LJ, Dorey TW, Jansen HJ, Liu Y, Jones DL, Rose RA. Distinct effects of ibrutinib and acalabrutinib on mouse atrial and sinoatrial node electrophysiology and arrhythmogenesis. J Am Heart Assoc 2021;10:e022369. ABSTRACT | PDF

Dorey TW, Jansen HJ, Moghtadaei M, Jamieson KL, Rose RA. Impacts of frailty on heart rate variability in aging mice: roles of the autonomic nervous system and sinoatrial node. Heart Rhyhtm 2021;18:1999-2008 ABSTRACT | PDF

Jansen HJ, Moghtadaei M, Rafferty SA, Rose RA. Atrial fibrillation in aging and frail mice: modulation by natriuretic peptide receptor C. Circ Arrhythm Electrophysiol 2021;14:e010077. ABSTRACT | PDF

Liu Y, Jansen HJ, Krishnaswamy P, Bogachev O, Rose RA. Impaired regulation of heart rate and sinoatrial node function by the parasympathetic nervous system in type 2 diabetic mice. Sci Rep 2021;11:12456. ABSTRACT | PDF

Aguilar M, Rose RA, Takawale A, Nattel S, Reilly S. New aspects of endocrine control of atrial fibrillation and possibilities for clinical translation. Cardiovasc Res 2021;117:1645-1661. ABSTRACT | PDF

Sun B, Yao J, Ni M, Wei J, Zhong X, Guo W, Zhang L, Wang R, Belke D, Chen Y-X, Lieve KVV, Broendberg AK, Roston TM, Blankoff I, Kammeraad JA, von Alvensleben J, Lazarte J, Vallmitjana A, Bohne LJ, Rose RA, Benitez R, Hove-Madsen L, Napolitano C, Hegele RA, Fill M, Sanatani S, Wilde AAM, Roberts JD, Priori SG, Jensen HK, Chen SRW. Cardiac ryanodine receptor calcium release deficiency syndrome. Sci Transl Med. 2021;13:eaba7287. ABSTRACT | PDF

Bohne LJ, Jansen HJ, Daniel I, Dorey TW, Moghtadaei M, Belke DD, Ezeani M, Rose RA. Electrical and structural remodeling contribute to atrial fibrillation in type 2 diabetic db/db mice. Heart Rhythm. 2021;18:118-129. ABSTRACT | PDF

Chakraborty P, Rose RA, Nair K, Downar, E, Nanthakumar K. The rationale for repurposing funny current inhibition for management of ventricular arrhythmia. Heart Rhythm 2021;18:130-137. ABSTRACT | PDF

Jansen HJ, Bohne LJ, Gillis AM, Rose RA. Atrial remodeling and atrial fibrillation in acquired forms of cardiovascular disease. Heart Rhythm O2. 2020;1:147-159. ABSTRACT | PDF

Dorey TW, Moghtadaei M, Rose RA. Altered heart rate variability in angiotensin II mediated hypertension is associated with impaired autonomic nervous system signaling and intrinsic sinoatrial node dysfunction. Heart Rhythm. 2020;17:1360-1370. ABSTRACT | PDF

Polina I, Jansen HJ, Li T, Moghtadaei M, Bohne LJ, Liu Y, Krishnaswamy P, Egom EE, Belke DD, Rafferty SA, Ezeani M, Gillis AM, Rose RA. Loss of insulin signaling may contribute to atrial fibrillation and atrial electrical remodeling in type I diabetes mellitus. Proc Natl Acad Sci USA. 2020;117:7990-8000. ABSTRACT | PDF

MacDonald EA, , Quinn TA. Neurohumoral control of sinoatrial node activity and heart rate: experimental insight and findings from humans. Front Physiol. 2020;11:170. ABSTRACT | PDF

Jansen HJ and Rose RA. Isolation of atrial myocytes from adult mice. J Vis Exp 2019;149:e59588. ABSTRACT | VIDEO

Ayaz O, Rose RA, WG Pyle, Howlett SE. Long term testosterone deficiency modifies myofilament and calcium handling proteins and promotes diastolic dysfunction in the aging mouse heart. Am J Physiol. 2019;316:H768-H780. ABSTRACT | PDF


Bohne LJ, Johnson D, Rose RA, Wilton SB, Gillis AM. The association between diabetes mellitus and atrial fibrillation: clinical and mechanistic insights. Front Physiol 2019;10:135. ABSTRACT | PDF


Jansen HJ, Mackasey M, Moghtadaei M, Liu Y, Kaur J, Egom EE, Tuomi JM, Rafferty SA, Kirkby AW, Rose RA. Natriuretic peptide receptor C modulates the progression of angiotensin II mediated atrial fibrillation and atrial remodeling in mice. Circ Arrhythmia Electrophysiol. 2019;12:e006863. ABSTRACT | PDF

Mackasey M, Egom EE, Jansen HJ, Hua R, Moghtadaei M, Liu Y, Kaur J, McRae M, Bogachev O, Rafferty SA, Ray G, Kirkby AW, Rose, RA. Natriuretic peptide receptor C (NPR-C) protects against angiotensin II mediated sinoatrial disease in mice. JACC: Bas Transl Sci 2018;3:824-843. ABSTRACT | PDF

Jansen HJ, Mackasey M, Moghtadaei M, Belke DD, Egom EE, Tuomi JM, Rafferty SA, Kirkby AW, Rose RA. Distinct patterns of atrial electrical and structural remodeling in angiotensin II mediated atrial fibrillation. J Mol Cell Cardiol 2018;124:12-25. ABSTRACT  | PDF

Govindipillai A, Hotchkiss A, Baguma-Nibasheka M, Rose RA, Miquerol L, Smithies O, Maeda N, Pasumarthi KBS. Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system. Sci Rep 2018;8:6939. ABSTRACT | PDF

Moghtadaei M, Langille E, Rafferty SA, Bogachev O, Rose RA. Altered heart rate regulation by the autonomic nervous system in mice lacking natriuretic peptide receptor C (NPR-C). Sci Rep 2017;7:17564. ABSTRACT | PDF

MacDonald EA, Stoyek MR, Rose RA, Quinn TA. Intrinsic regulation of sinoatrial node function and the zebrafish as a model of stretch effects on pacemaking. Prog Biophys Mol Biol 2017;130:198-211. ABSTRACT | PDF 

Parks RJ, Bogachev O, Mackasey M, Ray G, Rose RA, Howlett SE. The impact of ovariectomy on cardiac excitation-contraction coupling is mediated through cAMP/PKA-dependent mechanisms. J Mol Cell Cardiol 2017;111:51-60. ABSTRACT | PDF

Feridooni HA, Kane AE, Ayaz O, Boroumandi A, Polidovitch N, Tsushima RG, Rose RA, Howlett SE. The impact of age and frailty on ventricular structure and function in C57BL/6J mice. J Physiol 2017;595:3721-3742. ABSTRACT | PDF

Jansen HJ, Moghtadaei M, Mackasey M, Rafferty S, Bogachev O, Sapp JL, Howlett SE, Rose RA. Atrial structure, function and arrhythmogenesis in aged and frail mice. Sci Rep 2017;7:44336. ABSTRACT | PDF

Rockwood K, Blodgett JM, Theou O, Sun MH, Feridooni HA, Mitniski A, Rose RA, Godin J, Gregson E, Howlett SE. A frailty index based on deficit accumulation quantifies mortality risk in humans and in mice. Sci Rep 2017;7:43068. ABSTRACT | PDF

Moghtadaei M, Jansen HJ, Mackasey M, Rafferty S, Bogachev O, Sapp, JL, Howlett SE, Rose RA. The impacts of age and frailty on heart rate and sinoatrial node function. J Physiol 2016;594:7105-7126. ABSTRACT | PDF

Moghtadaei M, Polina I, Rose RA. Electrophysiological effects of natriuretic peptides are mediated by multiple receptor subtypes. Prog Biophys Mol Biol. 2016;120:37-49. ABSTRACT | PDF

Hua R, MacLeod S, Polina I, Moghtadaei M, Jansen HJ, Bogachev O, O’Blenes SB, Sapp JL, Legare JF, Rose RA. Effects of wildtype and mutant forms of atrial natriuretic peptide on atrial electrophysiology and arrhythmogenesis. Circ Arrhythm Electrophysiol 2015;8:1240-1254. ABSTRACT PDF

Krishnaswamy P, Egom EE, Moghtadaei M, Jansen HJ, Azer J, Bogachev O, Mackasey M, Robbins C, Rose RA. Impaired parasympathetic nervous system regulation of the sinoatrial node in Akita diabetic mice. J Mol Cell Cardiol 2015;82:125-135. ABSTRACT  |  PDF


Egom EE, Vella K, Hua R, Jansen H, Moghtadaei M, Polina I, Bogachev O, Hurnik R, Mackasey M, Rafferty S, Ray G, Rose RA. Impaired sinoatrial node function and increased susceptibility to atrial fibrillation in mice lacking natriuretic peptide receptor C (NPR-C). J Physiol 2015;593:1127-1146. (Selected as ‘Editor’s choice’ paper and for cover image). ABSTRACT  |  PDF


Langille MGI, Meehan CJ, Koenig JE, Dhanani A, Rose RA, Howlett SE, Beiko RG. Microbial shifts in the aging mouse gut. Microbiome 2014;2:50. ABSTRACT  |  PDF


Parks RJ, Ray G, Bienvenu LA, Rose RA, Howlett SE. Sex differences in SR calcium release in murine ventricular myocytes are regulated by the cAMP/PKA pathway. J Mol Cell Cardiol. 2014;75:162-173. ABSTRACT  |  PDF


Azer J, Hua R, Krishnaswamy PS, Rose RA. Effects of natriuretic peptides on electrical conduction in the sinoatrial node and atrial myocardium of the heart. J Physiol. 2014;592:1025-1045. (Selected for a virtual Journal of Physiology issue compiling the best cardiovascular papers of the year, including cover image, in August, 2014). ABSTRACT  |  PDF


Whitehead JC, Hildebrand BA, Sun M, Rockwood MRH, Rose RA, Rockwood K, Howlett SE. A simplified clinical frailty index in aging mice: comparisons with frailty data in humans. J Gerontol: Biol Sci. 2014;69:621-632. (Selected as 'Editor's Choice' paper). ABSTRACT  |  PDF


Fares E, Pyle WG, Ray G, Rose RA, Denovan-Wright E, Chen RP, Howlett SE. The impact of ovariectomy on calcium homeostasis and myofilament calcium sensitivity in the aging mouse heart. PLoS One 2013;8:e74719. ABSTRACT  |  PDF


Govindapillai A, Hua R, Rose RA, Hancock Friesen C, O’Blenes SB. Protecting the aged heart during cardiac surgery: use of delNido cardioplegia provides superior functional recovery in isolated hearts. J Thorac Cardiovasc Surg. 2013;146:940-948. ABSTRACT  |  PDF


Rose RA, Belke DD, Maleckar, MM, Giles WR. Ca2+ entry through TRP channels regulates fibroblast biology in chronic atrial fibrillation. Circulation 2012;126:2039. ABSTRACT  |  PDF


Hua R, Adamczyk A, Robbins C, Ray G, Rose RA. Distinct patterns of constitutive phosphodiesterase activity in mouse sinoatrial node and atrial myocardium. PLoS One 2012;7:e47652. ABSTRACT  |  PDF


Azer J, Vella K, Hua R, Rose RA. Natriuretic peptides regulate heart rate and sinoatrial node function by activating multiple natriuretic peptide receptors. J Mol Cell Cardiol 2012;53:715-724. ABSTRACT  |  PDF


Springer J, Azer J, Hua R, Adamczyk A, Robbins C, McBoyle S, Bissell MB, Rose RA. The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors. J Mol Cell Cardiol 2012;52:1122-1134. ABSTRACT  |  PDF


Rose RA. Keeping the clocks ticking as we age: changes in sinoatrial node gene expression and function in the aging heart. Exp Physiol 2011;96:1114-1115. ABSTRACT  |  PDF


Rose RA, Sellan M, Simpson JA, Izaddoustdar, F, Cifelli C, Panama BK, Davis M, Zhao D, Markhani M, Murphy GG, Striessnig J, Liu PP, Heximer SP, Backx PH. Iron-overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction and atrial fibrillation. Circ: Arrhythmia Electrophysiol 2011;4:733-742. ABSTRACT  |  PDF


Zhang S, Kim KH, Rosen A, Smyth JW, Sakukma R, Delgado-Olguin P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman G, Kim J, Rose RA, Marsden PA, Zhu  Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DYR, Shaw RM, Hui CC, Bruneau BG, Backx PH. Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc Nat Acad Sci USA 2011;108:13576-13581. ABSTRACT  |  PDF


Rose RA. CD-NP, a chimeric natriuretic peptide for the treatment of heart failure. Curr Opin Investig Drugs 2010;11:349-356. ABSTRACT  |  PDF


Cifelli C*, Rose RA*, Zhang H, Backx PH, Heximer SP. RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node. Circ Res 2008;103:527-535. *co-first authors. ABSTRACT  |  PDF


Rose RA and Giles WR. Natriuretic peptide C receptor (NPR-C) signaling in the heart and vasculature. J Physiol. 2008;586:353-366. ABSTRACT  |  PDF


Rose RA, Kabir MG and Backx PH. Altered heart rate and sinoatrial node function in mice lacking the cAMP regulator phosphoinositide 3-kinase-γ. Circ Res. 2007;101:1274-1282. ABSTRACT  |  PDF


Rose RA, Hatano N, Ohya S, Imaizumi Y and Giles WR. CNP activates a nonselective cation current in acutely isolated rat cardiac fibroblasts via NPR-C receptor mediated signaling. J Physiol. 2007;580:255-274. ABSTRACT  |  PDF


Kerfant B-G*, Rose RA*, Sun H and Backx PH. P13Kγ regulates cardiac contractility by locally controlling cAMP levels. Trends Cardiovasc Med 2006;16:250-255. *co-first authors. ABSTRACT  |  PDF


Rose RA, Lomax AE, Kondo CS, Anand-Srivastava MB, and Giles WR. Effects of C-type natriuretic peptide on ionic currents in mouse sinoatrial node: A role for the NPR-C receptor. Am J Physiol 2004;286:H1970-H1977. ABSTRACT  |  PDF


Rose RA, Lomax AE and Giles WR. Inhibition of L-type calcium current by C-type natriuretic peptide in bullfrog atrial myocytes: an NPR-C mediated effect. Am J Physiol 2003;285:H2454-H2462. ABSTRACT  |  PDF



Book Chapters


Jansen HJ, Quinn TA, Rose RA. Cellular sinoatrial node and atrioventricular node activity in the heart. In: Vasan R, Sawyer D (eds.). The Encyclopedia of Cardiovascular Research and Medicine. Elsevier (Oxford). 2018;567-592.

Jansen H and Rose RA. Natriuretic peptides: critical regulators of cardiac fibroblasts and the extracellular matrix in the heart. In: Cardiac Fibrosis and Heart Failure: Cause or Effect. Editors: Wigle J and Dixon I. pages 383-404. 2015.


Rose RA, Backx PH. Calcium channels in the Heart. In: Cardiac Electrophysiology from Cell to Bedside 6th Edition. Editors: Zipes D and Jalife J. pages 13-22. 2013.

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