Robert Rose - Principal Investigator
As the Principal Investigator of this laboratory I am interested in the cellular and molecular basis for cardiac arrhythmias in the setting of common forms of heart disease such as hypertesion, heart failure, and diabetes as well as in aging and frailty. Currently, we are particularly focused on sinoatrial node disease and atrial fibrillation, which are highly prevalent in these forms of heart disease.
My philosophy towards our research is that we will approach our scientific questions in multifaceted ways and search out new techniques or new collaborations whenever necessary to test our specific hypotheses. Our goal is to find new targets for intervention and new treatment strategies for heart disease.
Please feel free to contact me if you have questions about our research efforts.
Loryn Bohne - PhD Student
Loryn completed a BSc (Hons) in Biomedical Physiology at Simon Fraser University in B.C and joined our group initially as a Master's Student before transferring in the PhD program. Loryn is investigating the mechanistic basis for atrial fibrillation in the setting of diabetes mellitus. Loryn is using high resolution optical mapping, patch-clamping and molecular biology to conduct her studies, which are performed using mouse models of type 1 and type 2 diabetes.
Irene Daniel - Undergraduate/Honors Student
Irene is an undergraduate student in the Bachelor of Health Sciences program at the University of Calgary. She began in the lab as a volunteer and is currently an Honor's student. Irene is studying the role of fibrosis in atrial fibrillation in diabetes. Her experiments are conducted using histological approaches in type 1 and type 2 diabetes.
Tristan Dorey - PhD Student
Tristan completed a BSc (Hons) in Kinesiology at Dalhousie University in Halifax. He first became involved in our lab as a Summer Student and a volunteer. Tristan's studies as a graduate student are focused on the role of the autonomic nervous system and natriuretic peptides in sinoatrial node dysfunction in heart disease. Tristan is using telemetry, patch-clamping, high resolution optical mapping and molecular biology to conduct his studies.
Lockhart Jamieson - Postdoctoral Fellow
Lockhart completed her BSc at the University of Toronto and obtained her PhD at the University of Alberta where she investigated the impacts of epoxide hydrolase in ischemic heart disease in aging. Lockhart's research is focused on interventions to reduce frailty and how they impact atrial fibrillation and sinoatrial node disease in aging. Her experiments are conducted using in vivo electrophysiology, high resolution optical mapping and molecular biology.
Hailey Jansen - Postdoctoral Fellow
Hailey obtained BSc and MSc degrees from the University of British Columbia and a PhD degree from Dalhousie University, which was focused on atrial fibrillation in hypertensive heart disease and aging. Hailey uses intracardiac programmed stimulation, patch-clamping and molecular biology approaches to study cardiac function in vivo and in isolated tissues. Hailey’s current research is focused on the effects of natriuretic peptides on ion channel function and arrhythmogenesis in heart disease as well as aging and frailty.
Yingjie Liu - Postdoctoral Fellow
Yingjie completed a Bachelor of Clinical Medicine in Xiangya School of Medicine and a PhD at the University of Calgary, which was focused on the role of calcium handling in ventricular arrhythmias. Yingjie is currently investigating the basis for impaired autonomic regulation of the sinoatrial node in diabetes mellitus as well as the role of natriuretic peptides in the sinoatrial node and atria in heart failure. Her experiments are performed using molecular biology, calcium imaging and electrophysiological techniques.
Megan McRae - Laboratory Manager and Technician
Megan completed her undergraduate degree in the Bachelor of Health Sciences program at the University of Calgary. During that time, Megan worked in the lab as a summer student and then completed her Honour's thesis in the lab. Megan is now our Laboratory Manager and Technician. She conducts experimental work using a range of techniques, facilitates and assists other members of the lab with their work and helps manage the laboratory.
Motahareh Moghtadaei - Research Associate
Motahareh (Bahar) obtained her PhD in Biomedical Engineering from Tehran Polytechnic University. Bahar undertook postdoctoral fellowship training at Dalhousie University where she used telemetry ECG and high resolution optical mapping to study electrophysiology and arrhythmogenesis in heart failure, diabetes and aging/frailty. Bahar is investigating atrial arrhythmias in heart disease and aging.
Former laboratory members
Mary Beth Bissell